产品详情

  • 产品名称：Human IL-21 protein (Recombinant) (No-tag) (STJP001891)

  • 产品型号：STJP001891
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL-21 protein (Recombinant) (No-tag) (STJP001891)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-21-No-tag protein was developed from hek293 cells and has a target region of No-tag. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is 2.7-10.8 ng/mL, corresponding to a specific activity of 9.3×104~3.7×105 units/mg.
Gene Symbol: IL21
Gene ID: 59067
Uniprot ID: IL21_HUMAN
Immunogen Region: Gln32-Ser162
Immunogen: Recombinant Human IL-21 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Ser162) of human IL-21 (Accession #NP_068575.1) fused with no additional amino acid.
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Protein Name Interleukin-21
Il-21
Za11
Database Links Reactome: R-HSA-9020958
Cellular Localisation Secreted
Alternative Protein Names Interleukin-21 protein
Il-21 protein
Za11 protein
IL21 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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