产品详情

  • 产品名称：Anti-AFF4 antibody (1-220) (STJ22540)

  • 产品型号：STJ22540
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AFF4 antibody (1-220) (STJ22540)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AFF4 (1-220) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AFF4
Gene ID: 27125
Uniprot ID: AFF4_HUMAN
Immunogen Region: 1-220
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human AFF4 (NP_055238.1).
Immunogen Sequence: MNREDRNVLRMKERERRNQE IQQGEDAFPPSSPLFAEPYK VTSKEDKLSSRIQSMLGNYD EMKDFIGDRSIPKLVAIPKP TVPPSADEKSNPNFFEQRHG GSHQSSKWTPVGPAPSTSQS QKRSSGLQSGHSSQRTSAGS SSGTNSSGQRHDRESYNNSG SSSRKKGQHGSEHSKSRSSS PGKPQAVSSLNSSHSRSHGN DHHSKEHQRSKSPRDPDANW
Tissue Specificity Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.
Function Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
Protein Name Af4/Fmr2 Family Member 4
All1-Fused Gene From Chromosome 5q31 Protein
Protein Af-5q31
Major Cdk9 Elongation Factor-Associated Protein
Database Links Reactome: R-HSA-112382
Reactome: R-HSA-674695
Reactome: R-HSA-75955
Cellular Localisation Nucleus
Associates To Transcriptionally Active Chromatin But Not At Snrna Genes
Alternative Antibody Names Anti-Af4/Fmr2 Family Member 4 antibody
Anti-All1-Fused Gene From Chromosome 5q31 Protein antibody
Anti-Protein Af-5q31 antibody
Anti-Major Cdk9 Elongation Factor-Associated Protein antibody
Anti-AFF4 antibody
Anti-AF5Q31 antibody
Anti-MCEF antibody
Anti-HSPC092 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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