产品详情

  • 产品名称：Glutamate Receptor 2 Positive Control peptide (STJ504188)

  • 产品型号：STJ504188-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Glutamate Receptor 2 Positive Control peptide (STJ504188)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Glutamate Receptor 2 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GRIA2
Gene ID: 2891
Uniprot ID: GRIA2_HUMAN
Post Translational Modifications Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation. Ubiquitinated by RNF167, leading to its degradation.
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system. It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Peptide Name Glutamate Receptor 2
Glur-2
Ampa-Selective Glutamate Receptor 2
Glur-B
Glur-K2
Glutamate Receptor Ionotropic - Ampa 2
Glua2
Database Links Reactome: R-HSA-399710
Reactome: R-HSA-416993
Reactome: R-HSA-438066
Reactome: R-HSA-9022699
Reactome: R-HSA-9620244
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Postsynaptic Cell Membrane
Postsynaptic Density Membrane
Interaction With Cacng2
Cnih2 And Cnih3 Promotes Cell Surface Expression
Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons
Alternative Peptide Names Glutamate Receptor 2 protein
Glur-2 protein
Ampa-Selective Glutamate Receptor 2 protein
Glur-B protein
Glur-K2 protein
Glutamate Receptor Ionotropic - Ampa 2 protein
Glua2 protein
GRIA2 protein
GLUR2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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