产品详情

  • 产品名称：Anti-ADAMTS2 antibody (1029-1213) (STJ112310)

  • 产品型号：STJ112310
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ADAMTS2 antibody (1029-1213) (STJ112310)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ADAMTS2 (1029-1213) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADAMTS2
Gene ID: 9509
Uniprot ID: ATS2_HUMAN
Immunogen Region: 1029-1213
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1029-1213 of human ADAMTS2 (O95450).
Immunogen Sequence: PRNISDPSKKSYVVQWLSRP DPDSPIRKISSKGHCQGDKS IFCRMEVLSRYCSIPGYNKL CCKSCNLYNNLTNVEGRIEP PPGKHNDIDVFMPTLPVPTV AMEVRPSPSTPLEVPLNASS TNATEDHPETNAVDEPYKIH GLEDEVQPPNLIPRRPSPYE KTRNQRIQELIDEMRKKEML GKF
Tissue Specificity Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Function Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.
Protein Name A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2
Adam-Ts 2
Adam-Ts2
Adamts-2
Procollagen I N-Proteinase
Pc I-Np
Procollagen I/Ii Amino Propeptide-Processing Enzyme
Procollagen N-Endopeptidase
Pnpi
Database Links Reactome: R-HSA-1650814
Reactome: R-HSA-5083635
Reactome: R-HSA-5173214
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2 antibody
Anti-Adam-Ts 2 antibody
Anti-Adam-Ts2 antibody
Anti-Adamts-2 antibody
Anti-Procollagen I N-Proteinase antibody
Anti-Pc I-Np antibody
Anti-Procollagen I/Ii Amino Propeptide-Processing Enzyme antibody
Anti-Procollagen N-Endopeptidase antibody
Anti-Pnpi antibody
Anti-ADAMTS2 antibody
Anti-PCINP antibody
Anti-PCPNI antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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