产品详情

  • 产品名称：Anti-ADAM15 antibody (200-300) [S5MR] (STJ11102325)

  • 产品型号：STJ11102325
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ADAM15 antibody (200-300) [S5MR] (STJ11102325)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-ADAM15 (200-300) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S5MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADAM15
Gene ID: 8751
Uniprot ID: ADA15_HUMAN
Immunogen Region: 200-300
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ADAM15 (Q13444).
Immunogen Sequence: RHIRRRRDVVTETKTVELVI VADHSEAQKYRDFQHLLNRT LevalsLLDTFFRPLNVRVAL VGLEAWTQRDLVEISPNPAV TLENFLHWRRAHLLPRLPHD S
Tissue Specificity Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs.
Function Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Protein Name Disintegrin And Metalloproteinase Domain-Containing Protein 15
Adam 15
Metalloprotease Rgd Disintegrin Protein
Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15
Mdc-15
Metargidin
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-8941237
Cellular Localisation Endomembrane System
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Cell Projection
Cilium
Flagellum
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
The Majority Of The Protein Is Localized In A Perinuclear Compartment Which May Correspond To The Trans-Golgi Network Or The Late Endosome
The Pro-Protein Is The Major Detectable Form On The Cell Surface
Whereas The Majority Of The Protein In The Cell Is Processed
Alternative Antibody Names Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 15 antibody
Anti-Adam 15 antibody
Anti-Metalloprotease Rgd Disintegrin Protein antibody
Anti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 antibody
Anti-Mdc-15 antibody
Anti-Metargidin antibody
Anti-ADAM15 antibody
Anti-MDC15 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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