产品详情

  • 产品名称：Human CD8a protein (Recombinant) (C-hFc&His) (STJP001259)

  • 产品型号：STJP001259
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CD8a protein (Recombinant) (C-hFc&His) (STJP001259)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD8a-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human CD8A at 2 Mu g/mL (100 Mu L/well) can bind anti Human CD8A antibody with a linear range of 0.1-27.6ng/mL.
Gene Symbol: CD8A
Gene ID: 925
Uniprot ID: CD8A_HUMAN
Immunogen Region: Ser22-Asp182
Immunogen: Recombinant Human CD8a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser22-Asp182) of human CD8 alpha (Accession #NP_001759.3) fused with a Fc, 6×His tag at the C-terminus.
Tissue Specificity CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.
Post Translational Modifications Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts. O-glycosylated. Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Protein Name T-Cell Surface Glycoprotein Cd8 Alpha Chain
T-Lymphocyte Differentiation Antigen T8/Leu-2
Cd Antigen Cd8a
Database Links Reactome: R-HSA-198933
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Cd8a Localizes To Lipid Rafts Only When Associated With Its Partner Cd8b
Isoform 2: Secreted
Alternative Protein Names T-Cell Surface Glycoprotein Cd8 Alpha Chain protein
T-Lymphocyte Differentiation Antigen T8/Leu-2 protein
Cd Antigen Cd8a protein
CD8A protein
MAL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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