产品详情

  • 产品名称：ENAH Blocking Peptide for STJ506413 peptide (Phospho) (STJ506416)

  • 产品型号：STJ506416-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
ENAH Blocking Peptide for STJ506413 peptide (Phospho) (STJ506416)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Phospho-ENAH Blocking Peptide for STJ506413 is synthetically produced from the 710-760 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Dilution Range: ELISA 1:10, 000
IP 1:200
WB 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Enah
Gene ID: 13800
Uniprot ID: ENAH_MOUSE
Immunogen Region: 710-760
Specificity: This blocking peptide is recommended for use in combination with ENAH antibody, STJ506413
Tissue Specificity Expressed in heart and testis, lower levels in lung, skeletal muscle, kidney, pancreas and brain. Isoform 5 is expressed exclusively in the brain. Isoform 2 is expressed predominantly in brain, testis, ovary and fat. In the brain, isoforms 2 and 5 are expressed at highest levels in the hippocampus, cortex and midbrain, and at lowest levels in the striatum and cerebellum. Isoform 6 is expressed in brain and spleen.
Post Translational Modifications NTN1-induced PKA phosphorylation on Ser-255 directly parallels the formation of filopodial protrusions.
Function Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodsial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodsia formation.
Peptide Name Protein Enabled Homolog
Npc-Derived Proline-Rich Protein 1
Ndpp-1
Database Links Reactome: R-MMU-376176
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Lamellipodsium
Filopodium
Synapse
Cell Junction
Focal Adhesion
Targeted To The Leading Edge Of Lamellipodsia And Filopodia By Mrl Family Members
Colocalizes At Filopodial Tips With A Number Of Other Proteins Including Vinculin And Zyxlin
Colocalizes With N-Wasp At The Leading Edge
Colocalizes With Gphn And Pfn At Synapses
Alternative Peptide Names Protein Enabled Homolog protein
Npc-Derived Proline-Rich Protein 1 protein
Ndpp-1 protein
Enah protein
Mena protein
Ndpp1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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