产品详情

  • 产品名称：EHMT1/GLP1 Positive Control for STJ506055 peptide (STJ505801)

  • 产品型号：STJ505801-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
EHMT1/GLP1 Positive Control for STJ506055 peptide (STJ505801)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: EHMT1/GLP1 Positive Control for STJ506055 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EHMT1
Gene ID: 79813
Uniprot ID: EHMT1_HUMAN
Specificity: This is positive control is recommended for use in combination with EHMT1/GLP1 antibody STJ506055.
Immunogen: Purified protein.
Tissue Specificity Widely expressed.
Function Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B.
Peptide Name Histone-Lysine N-Methyltransferase Ehmt1
Euchromatic Histone-Lysine N-Methyltransferase 1
Eu-Hmtase1
G9a-Like Protein 1
Glp
Glp1
Histone H3-K9 Methyltransferase 5
H3-K9-Hmtase 5
Lysine N-Methyltransferase 1d
Database Links Reactome: R-HSA-2559582
Reactome: R-HSA-3214841
Reactome: R-HSA-6804760
Reactome: R-HSA-8853884
Reactome: R-HSA-8953750
Cellular Localisation Nucleus
Chromosome
Associates With Euchromatic Regions
Alternative Peptide Names Histone-Lysine N-Methyltransferase Ehmt1 protein
Euchromatic Histone-Lysine N-Methyltransferase 1 protein
Eu-Hmtase1 protein
G9a-Like Protein 1 protein
Glp protein
Glp1 protein
Histone H3-K9 Methyltransferase 5 protein
H3-K9-Hmtase 5 protein
Lysine N-Methyltransferase 1d protein
EHMT1 protein
EUHMTASE1 protein
GLP protein
KIAA1876 protein
KMT1D protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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