产品详情

  • 产品名称：Human Ephrin-A5/EFNA5 protein (Recombinant) (C-hFc&His) (STJP000951)

  • 产品型号：STJP000951
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Ephrin-A5/EFNA5 protein (Recombinant) (C-hFc&His) (STJP000951)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Ephrin-A5/EFNA5-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 0.5 Mu g/mL (100 Mu L/well) can bind Human EFNA5 with a linear range of 0.02-0.67 ng/mL.
Gene Symbol: EFNA5
Gene ID: 1946
Uniprot ID: EFNA5_HUMAN
Immunogen: Recombinant Human Ephrin-A5/EFNA5 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln21-Asn203) of human Ephrin-A5/EFNA5 (Accession #NP_001953.1) fused with an Fc, 6×His tag at the C-terminus.
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
Protein Name Ephrin-A5
Al-1
Eph-Related Receptor Tyrosine Kinase Ligand 7
Lerk-7
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Membrane
Caveola
Compartmentalized In Discrete Caveolae-Like Membrane Microdomains
Alternative Protein Names Ephrin-A5 protein
Al-1 protein
Eph-Related Receptor Tyrosine Kinase Ligand 7 protein
Lerk-7 protein
EFNA5 protein
EPLG7 protein
LERK7 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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