产品详情

  • 产品名称：Human EphA7/EHK-3 protein (Recombinant) (C-His) (STJP002731)

  • 产品型号：STJP002731
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human EphA7/EHK-3 protein (Recombinant) (C-His) (STJP002731)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human EphA7/EHK-3-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human EphA7 at 0.5 Mu g/mL (100 Mu L/well) can bind Human EFNA4 with a linear range of 0.039-0.942 ng/mL.
Gene Symbol: EPHA7
Gene ID: 2045
Uniprot ID: EPHA7_HUMAN
Immunogen Region: Met1-Val555
Immunogen: Recombinant Human EphA7/EHK-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Val555) of human EphA7 (Accession #NP_004431) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Phosphorylated.
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7.
Protein Name Ephrin Type-A Receptor 7
Eph Homology Kinase 3
Ehk-3
Eph-Like Kinase 11
Ek11
Hek11
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Ephrin Type-A Receptor 7 protein
Eph Homology Kinase 3 protein
Ehk-3 protein
Eph-Like Kinase 11 protein
Ek11 protein
Hek11 protein
EPHA7 protein
EHK3 protein
HEK11 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 
网站地图