产品详情

  • 产品名称：Human B7-H4 protein (Recombinant) (STJP000646)

  • 产品型号：STJP000646
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human B7-H4 protein (Recombinant) (STJP000646)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human B7-H4-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was tested by the ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes. The calculated ED50 is < 0.7 ug/ml NA
Gene Symbol: VTCN1
Gene ID: 79679
Uniprot ID: VTCN1_HUMAN
Immunogen Region: PHE29-ALA258
Immunogen: Optimized DNA sequence encoding mature chain of Human B7-H4 (PHE29-ALA258) including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Post Translational Modifications N-glycosylated.
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Protein Name V-Set Domain-Containing T-Cell Activation Inhibitor 1
B7 Homolog 4
B7-H4
B7h.5
Immune Costimulatory Protein B7-H4
Protein B7s1
T-Cell Costimulatory Molecule B7x
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Expressed At The Cell Surface
A Soluble Form Has Also Been Detected
Alternative Protein Names V-Set Domain-Containing T-Cell Activation Inhibitor 1 protein
B7 Homolog 4 protein
B7-H4 protein
B7h.5 protein
Immune Costimulatory Protein B7-H4 protein
Protein B7s1 protein
T-Cell Costimulatory Molecule B7x protein
VTCN1 protein
B7H4 protein
UNQ659 protein
PRO1291 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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