产品详情

  • 产品名称：Anti-ABCA2 antibody (STJA0009082)

  • 产品型号：STJA0009082
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ABCA2 antibody (STJA0009082)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP-binding cassette sub-family A member 2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCA2
Gene ID: 20
Uniprot ID: ABCA2_HUMAN
Specificity: This antibody detects endogenous levels of ABCA2 at Human, Rat
Immunogen: Synthesized peptide derived from human ABCA2
Post Translational Modifications Methylated at Gln-271 by N6AMT1.
Function Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
Protein Name Atp-Binding Cassette Sub-Family A Member 2
Atp-Binding Cassette Transporter 2
Atp-Binding Cassette 2
Database Links Reactome: R-HSA-1369062
Cellular Localisation Endosome Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Forms Discrete
Punctate Intracellular Vesicles
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family A Member 2 antibody
Anti-Atp-Binding Cassette Transporter 2 antibody
Anti-Atp-Binding Cassette 2 antibody
Anti-ABCA2 antibody
Anti-ABC2 antibody
Anti-KIAA1062 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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