产品详情

  • 产品名称：Human BMPR-1A/ALK-3 protein (Recombinant) (C-hFc&His) (STJP000931)

  • 产品型号：STJP000931
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human BMPR-1A/ALK-3 protein (Recombinant) (C-hFc&His) (STJP000931)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human BMPR-1A/ALK-3-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2B at 1 Mu g/mL (100 Mu L/well) can bind Human BMPRIA with a linear range of 0.5-62.5 ng/mL.
Gene Symbol: BMPR1A
Gene ID: 657
Uniprot ID: BMR1A_HUMAN
Immunogen: Active Recombinant Human BMPR-1A/ALK-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Arg152) of human BMPRIA/ALK-3/CD292 (Accession #NP_004320.2) fused with an Fc, 6×His tag at the C-term
Tissue Specificity Highly expressed in skeletal muscle.
Post Translational Modifications Glycosylated.
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2.
Protein Name Bone Morphogenetic Protein Receptor Type-1a
Bmp Type-1a Receptor
Bmpr-1a
Activin Receptor-Like Kinase 3
Alk-3
Serine/Threonine-Protein Kinase Receptor R5
Skr5
Cd Antigen Cd292
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Surface
Alternative Protein Names Bone Morphogenetic Protein Receptor Type-1a protein
Bmp Type-1a Receptor protein
Bmpr-1a protein
Activin Receptor-Like Kinase 3 protein
Alk-3 protein
Serine/Threonine-Protein Kinase Receptor R5 protein
Skr5 protein
Cd Antigen Cd292 protein
BMPR1A protein
ACVRLK3 protein
ALK3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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