产品详情

  • 产品名称：Anti-ABCG2 antibody [3G8] (STJ97809)

  • 产品型号：STJ97809
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ABCG2 antibody [3G8] (STJ97809)
详情介绍：
Host: Mouse
Applications: WB/IHC/IF/FC/ELISA
Reactivity: Human/Mouse/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Broad substrate specificity ATP-binding cassette transporter ABCG2 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications.
Clonality: Monoclonal
Clone ID: 3G8
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
FC 1:200-1:400
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCG2
Gene ID: 9429
Uniprot ID: ABCG2_HUMAN
Specificity: ABCG2 Monoclonal Antibody detects endogenous levels of ABCG2 protein.
Immunogen: Purified recombinant fragment of human ABCG2 expressed in E. Coli.
Post Translational Modifications N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional. Phosphorylated. Phosphorylation at Thr-362 by PIM1 is induced by drugs like mitoxantrone and is associated with cells increased drug resistance. It regulates the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.
Function Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates. Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability. Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux. In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation.
Protein Name Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2
Atp-Binding Cassette Sub-Family G Member 2
Breast Cancer Resistance Protein
Cdw338
Mitoxantrone Resistance-Associated Protein
Placenta-Specific Atp-Binding Cassette Transporter
Urate Exporter
Cd Antigen Cd338
Database Links Reactome: R-HSA-189451
Reactome: R-HSA-189483
Reactome: R-HSA-2161517
Reactome: R-HSA-917937
Reactome: R-HSA-9753281
Reactome: R-HSA-9793528
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Mitochondrion Membrane
Enriched In Membrane Lipid Rafts
Alternative Antibody Names Anti-Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2 antibody
Anti-Atp-Binding Cassette Sub-Family G Member 2 antibody
Anti-Breast Cancer Resistance Protein antibody
Anti-Cdw338 antibody
Anti-Mitoxantrone Resistance-Associated Protein antibody
Anti-Placenta-Specific Atp-Binding Cassette Transporter antibody
Anti-Urate Exporter antibody
Anti-Cd Antigen Cd338 antibody
Anti-ABCG2 antibody
Anti-ABCP antibody
Anti-BCRP antibody
Anti-BCRP1 antibody
Anti-MXR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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