产品详情

  • 产品名称：Anti-ABCB1 antibody (590-1280) (STJ113347)

  • 产品型号：STJ113347
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ABCB1 antibody (590-1280) (STJ113347)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-P Glycoprotein (590-1280) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCB1
Gene ID: 5243
Uniprot ID: MDR1_HUMAN
Immunogen Region: 590-1280
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 590-1280 of human P Glycoprotein (NP_000918.2).
Immunogen Sequence: STVRNADVIAGFDDGVIVEK GNHDELMKEKGIYFKLVTMQ TAGNEVELENAADESKSEID ALEMSSNDSRSSLIRKRSTR RSVRGSQAQDRKLSTKEALD
Tissue Specificity Expressed in small intestine. Expressed in liver, kidney and brain.
Function Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Protein Name Atp-Dependent Translocase Abcb1
Atp-Binding Cassette Sub-Family B Member 1
Multidrug Resistance Protein 1
P-Glycoprotein 1
Phospholipid Transporter Abcb1
Cd Antigen Cd243
Database Links Reactome: R-HSA-2161517
Reactome: R-HSA-382556
Reactome: R-HSA-9754706
Reactome: R-HSA-9757110
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Cytoplasm
Abcb1 Localization Is Influenced By C1orf115 Expression Levels (Plasma Membrane Versus Cytoplasm)
Localized To The Apical Membrane Of Enterocytes
Alternative Antibody Names Anti-Atp-Dependent Translocase Abcb1 antibody
Anti-Atp-Binding Cassette Sub-Family B Member 1 antibody
Anti-Multidrug Resistance Protein 1 antibody
Anti-P-Glycoprotein 1 antibody
Anti-Phospholipid Transporter Abcb1 antibody
Anti-Cd Antigen Cd243 antibody
Anti-ABCB1 antibody
Anti-MDR1 antibody
Anti-PGY1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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